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No interaction studies have been performed.
Vedolizumab has been studied in adult ulcerative colitis and Crohn's disease patients with concomitant administration of corticosteroids, immunomodulators (azathioprine, 6-mercaptopurine, and methotrexate), and aminosalicylates. Population pharmacokinetic analyses suggest that co-administration of such agents did not have a clinically meaningful effect on vedolizumab pharmacokinetics.
In adult patients with pouchitis, vedolizumab has been co-administered with antibiotics (see Pharmacology: Pharmacodynamics under Actions). The pharmacokinetics of vedolizumab in patients with pouchitis has not been studied (see Pharmacology: Pharmacokinetics under Actions).
The effect of vedolizumab on the pharmacokinetics of commonly co-administered medicinal compounds has not been studied.
Vaccinations: Live vaccines, in particular live oral vaccines, should be used with caution concurrently with vedolizumab (see Precautions).
