There is no experience of entecavir overdosage reported in patients. Healthy subjects who received single entecavir doses up to 40mg or multiple doses up to 20mg/day for up to 14 days had no increase in or unexpected adverse events. If overdose occurs, the patient must be monitored for evidence of toxicity, and standard supportive treatment applied as necessary. Following a single 1mg dose of entecavir, a 4-hour hemodialysis session removed approximately 13% of the entecavir dose.
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