Docetaxel Alcohol-free Main Life Caution For Usage

At preparation: Since the concentration of drug, etc. are different between this drug and other docetaxel preparation, do not use at the same time.
Since this drug is viscous, using of 18G injection needle is preferable for drawing it up into syringe.
*After injecting this drug to infusion solution (250ml or 500ml, physiological saline or 5% glucose solution), continue mixing procedure gently until complete dissolving and mixing can be confirmed visually. The recommended final concentration is 0.3-0.74 mg/mL.
After mixing with infusion solution (250ml or 500ml, physiological saline or 5% glucose solution), use it at once. However the chemical and physical stability of the infusion solution has been demonstrated for 24 hours when stored at room temperature (below 25°C), in non-PVC bag.
Do not co-infuse with other agents.
If this drug has contact with skin, immediately wash away with soap and plenty of running water. In addition, if it has contact with mucosa, immediately wash away with plenty of running water.
At administration: Be sure to administer intravenously over 1 hour or more. Do not administer this drug subcutaneously or intramuscularly.
At intravenous injection, leaking of the medicinal solution from the vessel may cause induration and necrosis at injection sites. Administer the medicinal solution in a way that it will not leak from the vessel.
Precautions for Handling: Stability test: Docetaxel Concentrate for Solution for Infusion 20 mg/1 mL: As a result of long term storage test using final container product (25°C, relative humidity 60%, for 3 years), appearance and contents were within the specified range. Thus Docetaxel Concentrate for Solution for Infusion 20 mg/1 mL was confirmed to be stable for 3 years under the usual market circulation.
Docetaxel Concentrate for Solution for Infusion 80 mg/4 mL: As a result of long term storage test using final container product (25°C, relative humidity 60%, for 3 years), appearance and contents were within the specified range. Thus, Docetaxel Concentrate for Solution for Infusion 80 mg/4 mL was confirmed to be stable for 3 years under the usual market circulation.