Initially 30 mg daily, may be used as maintenance dose if blood glucose is effectively controlled. May be increased to 60, 90 or 120 mg daily in successive steps if blood glucose is not adequately controlled. The interval between each dose increment should be at least 1 mth. Max: 120 mg daily.
Should be taken with food: Take immediately before meals. Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity to gliclazide, other sulfonylurea or sulfonamides. Type I diabetes; diabetic pre-coma & coma, diabetic ketoacidosis. Severe renal or hepatic insufficiency. Treatment w/ miconazole. Lactation.
Hypoglycaemia which may occur due to low-calorie diets, prolonged or strenuous exercise, alcohol intake, use w/ other hypoglycaemic agents, or presence of risk factors (eg, patient refuses or unable to cooperate, malnutrition, irregular mealtimes, imbalance between physical exercise & carbohydrate intake, renal & severe hepatic insufficiency, overdose, thyroid disorders, hypopituitarism & adrenal insufficiency). Inform patient of the importance of following dietary advice, taking regular exercise & regular monitoring of blood glucose levels. St. John's wort, fever, trauma, infection or surgery may affect blood glucose control. Reports of dysglycaemia w/ concomitant use of fluoroquinolones. Patients w/ G6PD-deficiency. Porphyric patients. Caution in driving or operating machinery. Avoid use during pregnancy. Safety & efficacy in childn & adolescents have not been established. 60-mg tab: Do not administer to patients w/ rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
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