Diagnogreen Description

Diagnogreen (Indocyanine green; ICG) is a dark, bluish-green dye introduced by Fox et al. (U.S.A.) in 1957. When injected intravenously, it binds itself immediately with serum protein and it is distributed in the blood of the whole body, taken up selectively by the liver and finally excreted from the liver into the bile in free form. As Diagnogreen is practically excreted neither from entero-hepatic circulation nor from the kidney and it is practically not seen in urine, it is a suitable dye to perform examinations of hepatic and circulatory functions.
Composition and Description: (See Table 1.)

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Diagnogreen Injection: Each vial contains 25mg of indocyanine green (ICG).
Attached solvent: 10ml (one ampoule) of J. P. water for injection per vial.
Generic name: indocyanine green.
Abbre.: ICG
Description: ICG is a dark bluish-green tricarbocyanic dye. It is soluble in water (a concentration of 11.6 w/v% at 20 °C), but practically insoluble in physiological saline and salt solution. It is slightly soluble in methanol and practically insoluble in acetone.
Wave-length of the maximum absorbance: 780nm in aqueous solution, but 805nm in protein-containing solution.
Stability: Unstable in aqueous solution, but stable in protein-containing solution or in dry form.