Not indicated for infusions lasting >24 hr. Use >24 hr has been associated w/ tolerance & tachyphylaxis & dose-related increase in adverse reactions. Risk of hypotension, bradycardia, & sinus arrest. Caution in patients w/ advanced heart block &/or severe ventricular dysfunction. Hypotension &/or bradycardia may be more pronounced in patients w/ hypovolemia, DM, or chronic HTN & in elderly patients. Caution w/ concomitant administration of other vasodilators or -ve chronotropic agents. Risk of transient HTN primarily during loading dose. Arousability should not be considered as evidence of lack of efficacy in the absence of other clinical signs & symptoms. Risk of w/drawal-related events. Possible clonidine-like w/drawal syndrome upon abrupt discontinuation. Discontinue if drug-related hyperthermia or pyrexia is suspected & monitor until body temp normalizes. Dose reduction of dexmedetomidine or other concomitant anesth, sedatives, hypnotics or opioids may be required when co-administered. Should not be co-administered through same IV catheter w/ blood or plasma. Incompatible when administered w/ amphotericin B or diazepam. Potential for absorption to some types of natural rubber. Dexmedetomidine crosses the placenta. Breastfed infant should be monitored for irritability. Safety & efficacy have not been established for ICU sedation in ped patients.
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