Dexmedetomidine B. Braun Concentrate for Solution for Infusion Dosage/Direction for Use

Dosing Guidelines: Dexmedetomidine dosing should be individualized and titrated to desired clinical response.
Dexmedetomidine is not indicated for infusions lasting longer than 24 hours.
Dexmedetomidine should be administered using a controlled infusion device.
Dosage Information: See Table 5.

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Dosage Adjustment: Due to possible pharmacodynamic interactions, a reduction in dosage of Dexmedetomidine or other concomitant anesthetics, sedatives, hypnotics or opioids may be required when co-administered [see Anesthetics, Sedatives, Hypnotics, Opioids under Interactions].
Dosage reductions may need to be considered for adult patients with hepatic impairment, and geriatric patients [see Hepatic Impairment under Precautions; Pharmacology: Pharmacokinetics under Actions].
Preparation of Solution: Strict aseptic technique must always be maintained during handling of Dexmedetomidine.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if product is discolored or if precipitate matter is present.
Dexmedetomidine must be diluted with 0.9% sodium chloride injection to achieve required concentration (4 mcg/ml) prior to administration. Preparation of solutions is the same, whether for the loading dose or maintenance infusion. After adding Dexmedetomidine to the diluent, shake gently to mix well. (See Table 6.)

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