Delamanid is an antibiotic. It is used together with other medicines to treat a lung infection known as tuberculosis (TB) that has become resistant to other antibiotics.
Take Delamanid exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Take this medicine together with food. Try to take it at the same time each day.
Delamanid is available as a film-coated tablet and a dispersible tablet.
If you are taking the dispersible tablet, dissolve it in a cup with 10 to 15 mL of water. Gently swirl to disperse the tablet evenly, then drink the suspension immediately. To ensure the full dose is taken, add another 10 to 15 mL of water to the same cup, mix well to disperse any remaining particles, and drink the suspension.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the severity of your infection and your response to the medication.
Take Delamanid at regular intervals. Do not skip any doses. You must complete the entire course of this medicine. If you don't, the infection will not be properly controlled.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Do not take Delamanid if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to this medicine or any of its ingredients.
Alert your doctor if you have a very low albumin level in the blood as Delamanid may not be suitable for you.
Do not take Delamanid with carbamazepine (medicine for fits or seizures).
Inform your doctor if you have the following conditions:
- history of arrhythmia (irregular or abnormal heartbeat) or bradycardia (slow heartbeat)
- congenital long QT syndrome (an inherited disease causing abnormally fast and erratic heartbeats)
- hypertrophic cardiomyopathy (abnormally thick heart muscle)
- severe high blood pressure
- heart failure (weakness and inability of the heart to pump blood)
- low potassium, magnesium or calcium levels in the blood
- liver disease
- severe kidney disease
Let your doctor know if you are pregnant or breastfeeding.
It is important that you do not get pregnant while being treated with this medicine. You may wish to discuss birth control methods with your doctor or pharmacist.
Why is it important to keep my appointments with the doctor?
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- ECG (a test used to record the electrical activity of the heart) must be done before and during treatment to know if this medicine is suited for you to take.
- Routine tests (e.g. electrolyte and albumin levels in the blood) may be done while you are being treated with this medicine.
What must I do to prevent spreading TB to other people?
TB is spread through the air, especially when you cough, sneeze or laugh. Always cover your mouth when you cough, sneeze or laugh. If you use tissue paper, seal it in a plastic bag before you throw it away. If you need to be around people for a long time, be sure to wear a mask that covers your mouth and nose to minimise the risk of passing the disease to other people.
You may still be able to infect others while undergoing treatment for TB. Your doctor may tell you to stay at home to avoid passing the disease to other people. You may need to sleep in a bedroom separate from your family members.
Be sure to finish the course of medication according to your doctor's instructions.
Delamanid may cause dizziness, headache, or tremors. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: nausea, vomiting, indigestion, loss of appetite, difficulty sleeping, and muscle spasms or weakness.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience a fast or abnormal heartbeat, chest pain, or if you pass out.
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not take Delamanid if you are taking carbamazepine (medicine for fits or seizures).
Inform your doctor and pharmacist if you are taking any of these medicines:
- medicines for irregular heartbeat e.g. amiodarone, disopyramide, dofetilide, procainamide, quinidine, sotalol
- medicines for HIV infection e.g. ritonavir, lopinavir
- certain antibiotics e.g. moxifloxacin, sparfloxacin, erythromycin, clarithromycin
- medicines for cold or allergy e.g. terfenadine, astemizole
- medicines for mood disorders e.g. chlorpromazine, haloperidol, thioridazine
- medicines for malaria (a disease characterised by chills, fever and sweating that is transmitted to people through the bite of an infected mosquito) e.g. halofantrine, quinine, chloroquine
- domperidone (medicine for nausea and vomiting)
- probucol (cholesterol-lowering medicine)
- methadone (medicine used to treat addiction to opioid [strong painkiller])
- cisapride (medicine for heartburn [burning pain in your chest caused by food or acid from your stomach that backs up into your mouth])
This list does not include all medicines that may interact with Delamanid.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Store in a cool, dry place away from the reach of children.
Keep the tablets in their original package to protect from moisture.
Medicines must not be used past the expiry date.
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