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Advise patients that allergic reactions, including serious allergic reactions, could occur and that serious reactions require immediate treatment. Patients should report any previous allergic reactions to daptomycin. [See Anaphylaxis/Hypersensitivity Reactions, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), and Tubulointerstitial Nephritis (TIN) under Precautions.]
Advise patients to report muscle pain or weakness, especially in the forearms and lower legs, as well as tingling or numbness. [See Myopathy and Rhabdomyolysis and Peripheral Neuropathy under Precautions.]
Advise patients to report any symptoms of cough, breathlessness, or fever. [See Eosinophilic Pneumonia under Precautions.]
Advise patients that diarrhea is a common problem caused by antibacterials that usually ends when the antibacterial is discontinued. Sometimes after starting treatment with antibacterials, patients can develop watery and bloody stools (with or without stomach cramps and fever), even as late as 2 or more months after having received the last dose of the antibacterial. If this occurs, patients should contact their physician as soon as possible. [See Clostridioides difficile-Associated Diarrhea under Precautions.]
Counsel patients that antibacterial drugs, including CUBICIN, should be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When CUBICIN is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be administered exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by CUBICIN or other antibacterial drugs in the future.
