Cozaar Description

COZAAR is available as tablets for oral administration containing either 50 mg or 100 mg of losartan potassium.
COZAAR 50 mg and 100 mg tablets contain potassium in the following amounts: 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively.
COZAAR (losartan potassium) is an angiotensin II receptor blocker acting on the AT₁ receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.
Its empirical formula is C₂₂H₂₂ClKN₆O.
Losartan potassium is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.
Excipients/Inactive Ingredients: COZAAR contains the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.
COZAAR 50 mg and COZAAR 100 mg may also contain carnauba wax.