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COLUMVI (glofitamab) injection is a sterile, preservative-free, colorless, clear solution supplied in single-dose vials for intravenous infusion.
Each mL of solution contains 1 mg glofitamab.
Glofitamab is a bispecific CD20-directed CD3 T-cell engager. It is a recombinant humanized anti-CD20 anti-CD3ɛ bispecific immunoglobulin G1 (IgG1) monoclonal antibody produced in Chinese hamster ovary (CHO) cells. Glofitamab has an approximate molecular weight of 197 kDa.
Excipients/Inactive Ingredients: Each mL of solution contains L-histidine (0.63 mg), L-histidine hydrochloride monohydrate (3.34 mg), L-methionine (1.49 mg), polysorbate 20 (0.5 mg), D-sucrose (82.15 mg), and Water for Injection, USP, at pH 5.5.
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