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One ml of Caelyx pegylated liposomal contains 2 mg doxorubicin hydrochloride in a pegylated liposomal formulation.
Caelyx pegylated liposomal is doxorubicin hydrochloride encapsulated in liposomes with surface-bound methoxypolyethylene glycol (MPEG). This process is known as pegylation and protects liposomes from detection by the mononuclear phagocyte system (MPS), which increases blood circulation time.
Excipients with known effect: Contains fully hydrogenated soy phosphatidylcholine (from soyabean) - see Contraindications.
Excipients/Inactive Ingredients: N-(Carbonyl-methoxypolyethyleneglycol 2000)-1,2-distearoyl-sn-glycero- 3-phosphoethanolamine sodium salt (MPEG-DSPE), fully hydrogenated soy phosphatidylcholine (HSPC), cholesterol, ammonium sulphate, sucrose, histidine, water for injections, hydrochloric acid (for pH-adjustment), sodium hydroxide (for pH-adjustment).
