Brevibloc Contraindications

BREVIBLOC (Esmolol Hydrochloride) injection is contraindicated in patients with: Hypersensitivity reactions, including anaphylaxis, to esmolol or any of the inactive ingredients of the product (cross-sensitivity between beta blockers is possible).
IV administration of cardiodepressant calcium-channel antagonists (e.g., verapamil) and BREVIBLOC injection in close proximity (i.e., while cardiac effects from the other are still present); fatal cardiac arrests have occurred in patients receiving BREVIBLOC injection and intravenous verapamil.
Severe sinus bradycardia: May precipitate or worsen bradycardia resulting in cardiogenic shock and cardiac arrest [see Bradycardia under Precautions].
Heart block greater than first degree: Second- or third-degree atrioventricular block may precipitate or worsen bradycardia resulting in cardiogenic shock and cardiac arrest [see Bradycardia under Precautions].
Sick sinus syndrome: May precipitate or worsen bradycardia resulting in cardiogenic shock and cardiac arrest [see Bradycardia under Precautions].
Decompensated heart failure: May worsen heart failure.
Cardiogenic shock: May precipitate further cardiovascular collapse and cause cardiac arrest.
Pulmonary hypertension: May precipitate cardiorespiratory compromise.