Bortezomib Alvogen Special Precautions

Patients must be advised to inform the doctor if they have any of the following: low numbers of red or white blood cells; bleeding problems and/or low number of platelets in the blood; diarrhoea, constipation, nausea or vomiting; fainting, dizziness or light-headedness in the past; kidney problems; moderate to severe liver problems; numbness, tingling, or pain in the hands or feet (neuropathy) in the past; heart or blood pressure problems; shortness of breath or cough; seizures; shingles (localised including around the eyes or spread across the body); symptoms of tumor lysis syndrome such as muscle cramping, muscle weakness, confusion, visual loss or disturbances and shortness of breath; memory loss, trouble thinking, difficulty with walking or loss of vision (these may be signs of a serious brain infection and further testing and follow-up may be suggested).
The patient will have to take regular blood tests before and during the treatment with Bortezomib Alvogen, to check the blood cell counts regularly.
If the patient has mantle cell lymphoma and is given the medicine rituximab with Bortezomib Alvogen, they must be advised to inform the doctor: if they think they have hepatitis infection now or have had it in the past. In a few cases, patients who have had hepatitis B might have a repeated attack of hepatitis, which can be fatal. If the patient has a history of hepatitis B infection, the patient will be carefully checked by the doctor for signs of active hepatitis B.
The package leaflets of all medicinal products to be taken must be read in combination with Bortezomib Alvogen for information related to these medicines before starting treatment with Bortezomib Alvogen. When thalidomide is used, particular attention to pregnancy testing and prevention requirements is needed (see Use in Pregnancy & Lactation).
Driving and using machines: Bortezomib Alvogen might cause tiredness, dizziness, fainting, or blurred vision. Patients must be advised not to drive or operate tools or machines if they experience such side effects; even if they do not, they should still be cautious.
Use in Children: Bortezomib Alvogen should not be used in children and adolescents because it is not known how the medicine will affect them.