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Mesalazine decreases the absorption of digoxin.
Mesalazine can increase the immunosuppresive effects of azathioprine and 6-mercaptopurine. A blood count, especially the leukocyte cell count should be monitored repeatedly, especially at initiation of such combination therapy.
The uricosuric activity of probenecid and sulfinpyrazone, the diuretic effect of furosemide and the activity of spironolactone can be reduced.
Gastrointestinal side-effects of glucocorticoids can be increased.
