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ARCOXIA is administered orally. ARCOXIA may be taken with or without food. ARCOXIA should be administered for the shortest duration possible and the lowest effective daily dose should be used.
In studies specifically designed to measure the onset of action of etoricoxib, the onset of action occurred as early as 24 minutes after dosing.
Osteoarthritis: The recommended dose is 30 mg or 60 mg once daily.
Rheumatoid Arthritis: The recommended dose is 60 mg once daily. In some patients with insufficient relief from symptoms, an increased dose of 90 mg once daily may increase efficacy. Once the patient is clinically stabilised, down-titration to a 60 mg once daily dose may be appropriate. In the absence of an increase in therapeutic benefit, other therapeutic options should be considered.
Ankylosing Spondylitis: The recommended dose is 60 mg once daily. In some patients with insufficient relief from symptoms, an increased dose of 90 mg once daily may increase efficacy. Once the patient is clinically stabilised, down-titration to a 60 mg once daily dose may be appropriate. In the absence of an increase in therapeutic benefit, other therapeutic options should be considered.
Acute Pain: Acute Gouty Arthritis: The recommended dose is 120 mg once daily.
ARCOXIA 120 mg should be used only for the acute symptomatic period, limited to a maximum of 8 days treatment.
Primary Dysmenorrhea: The recommended dose is 120 mg once daily.
ARCOXIA 120 mg should be used only for the acute symptomatic period, limited to a maximum of 8 days treatment.
Postoperative Dental Surgery Pain: The recommended dose is 90 mg once daily.
ARCOXIA should be used only for the acute symptomatic period, limited to a maximum of 3 days treatment. Some patients may require additional postoperative analgesia.
Doses greater than those recommended for each indication have either not demonstrated additional efficacy or have not been studied. Therefore: The dose for OA should not exceed 60 mg daily. The dose for RA should not exceed 90 mg daily. The dose for ankylosing spondylitis should not exceed 90 mg daily. The dose for acute gout should not exceed 120 mg daily. The dose for primary dysmenorrhea should not exceed 120 mg daily. The dose for postoperative dental surgery pain should not exceed 90 mg daily.
As the cardiovascular risks of selective COX-2 inhibitors may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used. The patient's need for symptomatic relief and response to therapy should be re-evaluated periodically. (See Precautions.)
Elderly, Gender, Race: No dosage adjustment in ARCOXIA is necessary for the elderly or based on gender or race.
Hepatic Insufficiency: In patients with mild hepatic insufficiency (Child-Pugh score 5-6), a dose of 60 mg once daily should not be exceeded. In patients with moderate hepatic insufficiency (Child-Pugh score 7-9), the dose should be reduced; a dose of 60 mg every other day should not be exceeded, administration of 30 mg once daily can also be considered. There is no clinical experience in patients with severe hepatic dysfunction (Child-Pugh score ≥10); therefore, its use is contraindicated in these patients. (See Contraindications and Precautions.)
Renal Insufficiency: The use of etoricoxib in patients with advanced renal disease (creatinine clearance <30 mL/min) is contraindicated (see Contraindications). No dosage adjustment is necessary for patients with lesser degrees of renal insufficiency (creatinine clearance ≥30 mL/min). (See Precautions.)
