Like all medicines, this medicine can cause side effects, although not everybody gets them.
Tell the doctor immediately and stop taking Aray: if experiencing weakness, feeling light-headed or dizzy or having difficulty breathing, as these may be signs of a serious allergic reaction; if a skin rash or ulcers develop in the mouth, as these may indicate severe, sometimes life-threatening reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, Drug Reaction with Eosinophilia and Systemic Symptoms [DRESS]) (see Precautions).
Tell the doctor immediately if experiencing: pale skin, tiredness, or bruising, as these may indicate blood disorders caused by an imbalance in the different types of blood cells which make up blood; tiredness, abdominal pain, or jaundice (yellow discolouration of the eyes or skin), as these may indicate serious conditions such as liver failure, which may be fatal; any symptoms of an infection such as fever, sore throat or cough, as this medicine may increase the chance of a severe infection which may be life-threatening; cough or breathing problems, as these may indicate problems of the lung (interstitial lung disease or pulmonary hypertension); unusual tingling, weakness or pain in the hands or feet, as these may indicate problems with the nerves (peripheral neuropathy).
Common side effects (may affect up to 1 in 10 people): a slight decrease in the number of white blood cells (leucopenia); mild allergic reactions; loss of appetite, weight loss (usually insignificant); tiredness (asthenia); headache, dizziness; abnormal skin sensations like tingling (paraesthesia); mild increase in blood pressure; colitis; diarrhoea; nausea, vomiting; inflammation of the mouth or mouth ulcers; abdominal pain; an increase in some liver test results; increased hair loss; eczema, dry skin, rash, itching; tendonitis (pain caused by inflammation in the membrane surrounding the tendons usually in the feet or hands); an increase of certain enzymes in the blood (creatine phosphokinase); problems in the nerves of the arms or legs (peripheral neuropathy).
Uncommon side effects (may affect up to 1 in 100 people): a decrease in the number of red blood cells (anaemia) and a decrease in the number of blood platelets (thrombocytopenia); a decrease in the levels of potassium in the blood; anxiety; taste disturbances; urticaria (nettle rash); tendon rupture; an increase in the levels of fat in the blood (cholesterol and triglycerides); a decrease in the levels of phosphate in the blood.
Rare side effects (may affect up to 1 in 1,000 people): an increase in the number of blood cells called eosinophils (eosinophilia), mild decrease in the number of white blood cells (leucopenia), decrease in the number of all blood cells (pancytopenia); severe increase in blood pressure; inflammation of the lung (interstitial lung disease); an increase in some liver results which may develop into serious conditions such as hepatitis and jaundice; severe infections called sepsis which may be fatal; an increase of certain enzymes in the blood (lactate dehydrogenase).
Very rare side effects (may affect up to 1 in 10,000 people): a marked decrease of some white blood cells (agranulocytosis); severe and potentially severe allergic reactions; inflammation of the small vessels (vasculitis, including cutaneous necrotizing vasculitis); inflammation of the pancreas (pancreatitis); severe liver injury such as liver failure or necrosis which may be fatal; severe sometimes life-threatening reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme).
Other side effects such as kidney failure, a decrease in the levels of uric acid in the blood, pulmonary hypertension, male infertility (which is reversible once treatment with this medicine is stopped), cutaneous lupus (characterized by rash/erythema on skin areas that are exposed to light), psoriasis (new or worsening) and DRESS may also occur with an unknown frequency.
Reporting of side effects: If any side effects occur, talk to the doctor or pharmacist. This includes any possible side effects not previously listed. By reporting side effects, more information on the safety of this medicine can be provided.