Apo-Pramipexole Drug Interactions

Drug-Drug Interactions: The drugs listed in Table 10 are based on information collected in clinical studies, interaction case reports, or pharmacological properties of the drug that may be used. See Pharmacology: Pharmacokinetics: Drug-drug interactions under Actions for more information.
Pramipexole dihydrochloride monohydrate is bound to plasma proteins to a very low extent (<20%) and little biotransformation is seen in humans. Therefore, interactions with other medication affecting plasma protein binding or elimination by biotransformation are unlikely. Medication that inhibit the active renal tubular secretion of basic (cationic) drugs or are themselves eliminated by active renal tubular secretion may interact with pramipexole dihydrochloride monohydrate resulting in reduced clearance of either or both medications. (See Table 10.)

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Drug-Food Interactions: Interactions with food have not been established.
Drug-Herb Interactions: Interactions with herbal products have not been established.
Drug-Laboratory Interactions: There are no known interactions between pramipexole dihydrochloride monohydrate and laboratory tests.