The patient should always tell the doctor about all drugs he/she is taking or plans to take, including those obtained without a prescription, vitamins, and herbal products.
It is likely that calcium supplements, antacids, and some oral medicines will interfere with the absorption of alendronate if taken at the same time of the day. The patient must wait at least one-half hour after taking APO-ALENDRONATE / VITAMIN D3 before taking any other oral medication.
It is likely that certain medicines or food additives may prevent the vitamin D in APO-ALENDRONATE / VITAMIN D3 from getting into the body, including artificial fat substitutes, mineral oils, orlistat and the cholesterol-lowering medicines, cholestyramine and colestipol. Medicines for seizures (convulsions), cimetidine and thiazides (diuretic) may decrease the effectiveness of vitamin D.