Amlodipine/Valsartan Teva Drug Interactions

Tell the doctor or pharmacist if the patient is taking, has recently taken or might take any other medicines. The doctor may need to change the dose and/or to take other precautions. In some cases the patient may have to stop taking one of the medicines. This applies especially to the medicines listed as follows.
ACE inhibitors, other RAAS-acting agent or aliskiren: Clinical trial data has shown that dual blockade of the RAAS through the combined use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia and decreased renal function (including acute renal failure) compared to the use of a single RAAS-acting agent (see also Contraindications and Precautions).
Diuretics (a type of medicine also called "water tablets" which increases the amount of urine produced).
Lithium (a medicine used to treat some types of depression).
Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium and other substances that may increase potassium levels.
Certain types of painkillers called non-steroidal anti-inflammatory medicines (NSAIDs) or selective cyclooxygenase-2 inhibitors (COX-2 inhibitors). The doctor may also check the kidney function.
Anticonvulsant agents (e.g. carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone).
St. John's wort.
Nitroglycerin and other nitrates, or other substances called "vasodilators".
Medicines used for HIV/AIDS (e.g. ritonavir, indinavir, nelfinavir).
Medicines used to treat fungal infections (e.g. ketoconazole, itraconazole).
Medicines used to treat bacterial infections (such as rifampicin, erythromycin, clarithromycin, telithromycin).
Verapamil, diltiazem (heart medicines).
Simvastatin (a medicine used to control high cholesterol levels).
Dantrolene (infusion for severe body temperature abnormalities).
Medicines used to protect against transplant rejection (ciclosporin).
Amlodipine/Valsartan Teva Tablets with food and drink: Grapefruit and grapefruit juice should not be consumed by people who are taking Amlodipine/Valsartan Teva Tablets. This is because grapefruit and grapefruit juice can lead to an increase in the blood levels of the active substance amlodipine, which can cause an unpredictable increase in the blood pressure lowering effect of Amlodipine/Valsartan Teva Tablets.