Amaryl Drug Interactions

Tell the doctor or pharmacist if the patient is taking, has recently taken or might take any other medicines.
The doctor may wish to change the dose of Amaryl if the patient is taking other medicines, which may weaken or strengthen the effect of Amaryl on the level of sugar in the blood.
The following medicines can increase the blood sugar lowering effect of Amaryl. This can lead to a risk of hypoglycaemia (low blood sugar): Other medicines to treat diabetes mellitus (such as insulin or metformin).
Medicines to treat pain and inflammation (phenylbutazone, azopropazone, oxyphenbutazone, aspirin-like medicines).
Medicines to treat urinary infections (such as some long acting sulphonamides).
Medicines to treat bacterial and fungal infections (tetracyclines, chloramphenicol, fluconazole, miconazole, quinolones, clarithromycin).
Medicines to inhibit blood clotting (coumarin derivatives such as warfarin).
Medicines supporting muscle build up (anabolics).
Medicines used for male sex hormone replacement therapy.
Medicines to treat depression (fluoxetine, MAO-inhibitors).
Medicines lowering high cholesterol level (fibrates).
Medicines lowering high blood pressure (ACE inhibitors).
Medicines called anti-arrhythmic agents used to control abnormal heart beat (disopyramide).
Medicines to treat gout (allopurinol, probenecid, sulfinpyrazone).
Medicines to treat cancer (cyclophosphamide, ifosfamide, trofosfamide).
Medicines used to reduce weight (fenfluramine).
Medicines to increase circulation when given in a high dose intravenous infusion (pentoxifylline).
Medicines to treat nasal allergies such as hay fever (tritoqualine).
Medicines called sympatholytics to treat high blood pressure, heart failure, or prostate symptoms.
The following medicines may decrease the blood sugar lowering effect of Amaryl. This can lead to a risk of hyperglycaemia (high blood sugar level): Medicines containing female sex hormones (oestrogens, progestogens).
Medicines to treat high blood pressure called thiazide diuretics (water tablets).
Medicines used to stimulate the thyroid gland (such as levothyroxine).
Medicines to treat allergies and inflammation (glucocorticoids).
Medicines to treat severe mental disorders (chlorpromazine and other phenothiazine derivatives).
Medicines used to raise heart beat, to treat asthma or nasal congestion, coughs and colds, used to reduce weight, or used in life-threatening emergencies (adrenaline and sympathomimetics).
Medicines to treat high cholesterol level (nicotinic acid).
Medicines to treat constipation when they are used long term (laxatives).
Medicines to treat fits (phenytoin).
Medicines to treat nervousness and sleep problems (barbiturates).
Medicines to treat increased pressure in the eye (azetazolamide).
Medicines to treat high blood pressure or low blood sugar (diazoxide).
Medicines to treat infections, tuberculosis (rifampicine).
Medicines to treat severe low blood sugar levels (glucagon).
The following medicines can increase or decrease the blood sugar lowering effect of Amaryl: Medicines to treat stomach ulcers (called H2 antagonists).
Medicines to treat high blood pressure or heart failure such as beta-blockers, clonidine, guanethidine and reserpine. These can also hide the signs of hypoglycaemia, so special care is needed when taking these medicines.
Amaryl may either increase or weaken the effects of the following medicines: Medicines inhibiting blood clotting (coumarin derivatives such as warfarin).
Colesevelam, a medicine used to reduce cholesterol, has an effect on the absorption of Amaryl. To avoid this effect, the patient should be advised to take Amaryl at least 4 hours before colesevelam.
Amaryl with food, drink and alcohol: Alcohol intake may increase or decrease the blood sugar lowering action of Amaryl in an unpredictable way.