Aluminium hydroxide: Uses, Dosage, Side Effects an...

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Hong Kong prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Antacid

Adult: As tab: 600-1,200 mg 3-4 times daily. As oral susp: 640 mg 5-6 times daily up to a Max of 3,840 mg/24 hours. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).

Oral
Hyperphosphataemia in patients with chronic renal failure

Adult: As tab: 600-1,200 mg 3-4 times daily. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).

Topical/Cutaneous
Skin protectant

Adult: As 2% gel: Apply onto the affected area(s) as needed or as prescribed. Dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).

What are the brands available for Aluminium hydroxide in Hong Kong?

Alu-Tab

Administration

Aluminium hydroxide Should be taken with food. Oral susp: Shake well before use.

Special Precautions

Patient with uraemia, heart failure, oedema, recent gastrointestinal haemorrhage, cirrhosis. Patients on low Na diet. Not recommended for use in patients with hypophosphataemia. Elderly. Pregnancy and lactation.

Adverse Reactions

Significant: Constipation, aluminium intoxication, osteomalacia, osteoporosis; hypophosphataemia (prolonged use or large doses).
Gastrointestinal disorders: Nausea, vomiting, stomach cramps, faecal impaction, faecal discolouration.
Metabolism and nutrition disorders: Hypomagnesaemia.

Monitoring Parameters

When used for hyperphosphataemia in patients with chronic renal failure: Monitor Ca and phosphorous levels and serum Al levels.

Action

Description:
Mechanism of Action: Aluminium hydroxide is an inorganic salt. It neutralises hydrochloride in the stomach, thereby causing elevated gastric pH and inhibition of pepsin activity. Additionally, it binds phosphate in the gastrointestinal tract, forming insoluble complexes, thus preventing the absorption of phosphate. As a topical agent, it provides temporary relief and protection for certain skin conditions.
Duration: 20-60 minutes (fasting state); up to 3 hours (1 hour after meals).
Pharmacokinetics:
Excretion: Via urine (17-30%); forms a combination with dietary phosphate in the intestine and is excreted in the faeces.

Chemical Structure

Storage

Store at room temperature. Protect from freezing.

MIMS Class

Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02AB01 - aluminium hydroxide ; Belongs to the class of aluminium-containing antacids.

References

Alu-Tab (iNova Pharmaceuticals [Hong Kong] Limited). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 11/09/2024.

Aluminium [Aluminum] Hydroxide. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 11/09/2024.

Aluminum Hydroxide Liquid (Rugby Laboratories). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 11/09/2024.

Aluminum Hydroxide. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 11/09/2024.

Astoneagran Ointment (Astonea Labs Private Limited). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 11/09/2024.

Brayfield A, Cadart C (eds). Aluminium Hydroxide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 11/09/2024.

Disclaimer: This information is independently developed by MIMS based on Aluminium hydroxide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com