Anxiety States: Symptoms include anxiety, tension, agitation, insomnia, apprehension, irritability and/or autonomic hyperactivity resulting in a variety of somatic complaints.
Mixed Anxiety-Depression: Symptoms of both anxiety and depression occur simultaneously.
Neurotic or Reactive Depression: Patients show a depressed mood or a pervasive loss of interest or pleasure. Symptoms include anxiety, psychomotor agitation and insomnia. Other characteristics are appetite disturbances, changes in weight, somatic complaints, cognitive disturbances, decreased energy, feeling of worthlessness or guilt or thoughts of death or suicide.
Alprazolam should not be used in patients whose primary symptom of depression is psychomotor retardation; with a diagnosis of bipolar depression; with psychotic symptoms.
Anxiety states, mixed anxiety-depression or neurotic depression associated with other diseases, eg the chronic phase of alcohol withdrawal and functional or organic disease, particularly certain gastrointestinal, cardiovascular or dermatological disorders.
Alprazolam is also indicated for the treatment of panic disorder, with or without agoraphobia.
The effectiveness of Alprazolam for long-term use exceeding 6 months has not been established.
The physician should reassess the usefulness of the drug for the individual patient from time to time.