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Blood and lymphatic system disorders: Agranulocytosis, aplastic anaemia, thrombocytopenia.
Immune system disorders: Hypersensitivity, angioimmunoblastic T-cell lymphoma, anaphylactic reaction.
Metabolism and nutrition disorders: Diabetes mellitus, hyperlipidaemia.
Psychiatric disorders: Depression.
Nervous system disorders: Coma, paralysis, ataxia, neuropathy peripheral, paraesthesia, somnolence, headache, dysgeusia.
Eye disorders: Cataract, visual impairment, maculopathy.
Ear and labyrinth disorders: Vertigo.
Cardiac disorders: Angina pectoris, bradycardia.
Vascular disorders: Hypertension.
Gastrointestinal disorders: Vomiting, nausea, haematemesis, steatorrhea, stomatitis, change of bowel habit, diarrhoea.
Hepatobiliary disorders: Liver function test abnormal, hepatitis.
Skin and subcutaneous tissue disorders: Rash, Stevens-Johnson syndrome/toxic epidermal necrolysis, angioedema, drug eruption, alopecia, hair colour changes.
Renal and urinary disorders: Haematuria, azotaemia.
Reproductive system and breast disorders: Infertility male, erectile dysfunction, gynaecomastia.
General disorders and administration site conditions: Oedema, malaise, asthenia, pyrexia.
Investigations: Blood thyroid stimulating hormone increased.
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