Agrylin Patient Counseling Information

Dose: Tell the patient that their dose will be adjusted on a weekly basis until they are on a dose that lowers their platelets to an appropriate level. This will also help the patient to adjust to common side effects. Tell the patient to contact their doctor if they experience tolerability issues, so the dose or dosing frequency can be adjusted [see Dosage & Administration].
Cardiovascular effects: Tell the patient to contact a doctor immediately if they experience chest pain, palpitations, or feel their heartbeat is irregular [see Cardiovascular Toxicity under Precautions].
Risk of Pulmonary Hypertension: Tell the patient to contact a doctor immediately if they experience shortness of breath, swelling in legs or ankles, or lips and skin turn a bluish color [see Pulmonary Hypertension under Precautions].
Risk of bleeding: Warn the patient that concomitant aspirin (or other medicines that affect blood clotting) may increase the risk of bleeding. Tell the patient to contact a doctor immediately if they experience signs or symptoms of bleeding (e.g., vomit blood, pass bloody or black stools) or experience unexplained bruising/bruise more easily than usual [see Bleeding Risk under Precautions; Aspirin and Drugs that Increase Bleeding Risk under Interactions].
Lactation: Advise patients not to breastfeed during treatment with AGRYLIN, and for one week following the last dose [see Lactation under Use in Pregnancy & Lactation].
Infertility: Advise females of reproductive potential that treatment with AGRYLIN may impair fertility [see Females and Males of Reproductive Potential under Use in Pregnancy & Lactation; Pharmacology: Toxicology: Nonclinical Toxicology: Carcinogenesis, Mutagenesis, Impairment of Fertility under Actions].