Reported experience with overdose in humans is very limited. Single doses of up to 70 mg have been given with acceptable acute tolerability in the adult population. General supportive measures should be initiated in all cases of overdose.
Tablet (Tuberous Sclerosis Complex-Related Indications) and Dispersible tablet: It is essential to assess everolimus blood levels in cases of suspected overdose.
Everolimus is not considered dialysable to any relevant degree (less than 10% was removed within 6 hours of haemodialysis).
Paediatric population: A limited number of paediatric patients have been exposed to doses higher than 10 mg/m2/day. No signs of acute toxicity have been reported in these cases.