Acertil Plus Contraindications

Linked to perindopril: Hypersensitivity to the active substance or to any other ACE inhibitor; History of angioedema (Quincke's oedema) associated with previous ACE inhibitor therapy (see Warnings); Hereditary/idiopathic angioedema; Second and third trimesters of pregnancy (see Warnings and Use in Pregnancy & Lactation); Concomitant use of ACERTIL PLUS with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m²) (see Interactions and Pharmacology: Pharmacodynamics under Actions); Concomitant use with sacubitril/valsartan (see Warnings and Interactions); Extracorporeal treatments leading to contact of blood with negatively charged surfaces (see Interactions); Significant bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney (see Precautions).
Linked to indapamide: Hypersensitivity to the active substance or to any other sulphonamides; Severe renal impairment (creatinine clearance below 30 ml/min); Hepatic encephalopathy; Severe hepatic impairment; Hypokalaemia; Lactation (see Use in Pregnancy & Lactation).
As a general rule, this medicine is inadvisable in combination with non-antiarrhythmic agents causing torsades de pointes (see Interactions).
Linked to ACERTIL PLUS: Hypersensitivity to any of the excipients listed in Description.
Due to the lack of sufficient therapeutic experience, ACERTIL PLUS should not be used in: Dialysis patients; Patients with untreated decompensated heart failure.