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Microbiome-derived deoxycholic acid (DCA) worsens portal hypertension by boosting TPH1-dependent 5-hydroxytryptamine (5-HT) biosynthesis, which activates portal vein smooth muscle cell contraction via HTR1A-GIRK3 signalling, a study has found.

Arginine therapy is no better than placebo in terms of improving outcomes in children and young adults with sickle cell disease (SCD) who are experiencing acute pain episodes, according to the phase III STArT trial.

Among people living with HIV who are initiating antiretroviral therapy (ART), those with obesity potentially face a higher long-term risk of cardiovascular disease (CVD), cancer, or death, according to an observational study.

Measurements of rituximab serum concentration are predictive of future drug concentrations associated with early B-cell repopulation in children with inflammatory diseases, suggests a study.

An association exists between daily glucocorticoid (GC) dose and worse patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE) who have achieved Lupus Low Disease Activity State (LLDAS), even after adjustments for potential confounders, according to a study.

Use of aspirin after curative-intent treatment of colorectal cancer (CRC) liver metastases does not appear to improve disease-free survival and is even associated with reduced overall survival and more serious adverse events (AEs), according to the phase III ASAC trial

Use of statins is associated with a lower incidence of remote seizures following a first status epilepticus event, according to a retrospective study.