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Nivolumab plus chemo offers prolonged survival in resectable NSCLC
Patients with resectable nonsmall cell lung cancer (NSCLC) enjoy sustained survival from neoadjuvant nivolumab when added to chemotherapy compared with chemotherapy alone, as seen in the 4-year analysis from the phase III CheckMate 816 study.

Are fertility treatments safe in young breast cancer survivors who have high-risk genes?
In young breast cancer survivors harbouring BRCA1/2 pathogenic variants, using assisted reproductive techniques (ART) to conceive did not appear to negatively affect maternal or pregnancy outcomes, findings from an international retrospective cohort study suggest.

Olaparib extends survival in gBRCA-mutated breast cancer
The intermittent 48-h “gap” schedule of olaparib in combination with carboplatin/paclitaxel and anthracycline chemotherapy provides substantial survival benefits in patients with germline BRCA-mutated breast cancer (gBRCA) regardless of their pathological complete response (pCR) status, results of the PARTNER trial have shown.

Add-on bispecific antibody may alter treatment landscape of G/GEJ cancer
Adding the PD-1/CTLA-4 bispecific antibody cadonilimab to chemotherapy improves overall survival (OS) and progression-free survival (PFS) in individuals with untreated, HER2-negative, locally advanced or metastatic gastric or gastroesophageal junction (G/GEJ) cancer, including patients with PD-L1–low tumours, according to the interim results of the phase III COMPASSION-15 trial.

Chemo plus immunotherapy improves survival in advanced endometrial cancer
Adding immunotherapy to the first-line treatment for advanced and metastatic endometrial cancer may significantly improve some oncologic outcomes, particularly within the mismatch repair deficiency/microsatellite instability-hypermutated (MMRd/MSI-H) subset, suggests a study.



