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Dextromethorphan-bupropion relieves symptoms in major depressive disorder
Treatment with dextromethorphan-bupropion (AXS-05) significantly improves depressive symptoms relative to bupropion alone and is well tolerated in patients with major depression, results of a phase II trial have shown.

Ozoralizumab shows therapeutic potential in rheumatoid arthritis
Treatment with the next-generation anti-TNFα antibody yields marked improvements in the signs and symptoms of rheumatoid arthritis in patients with inadequate response to methotrexate (MTX), while having an acceptable safety profile, as shown in the phase II/III OHZORA trial.

Ventral striatum connectivity may predict depression in adolescence
The connectivity strength of the ventral striatum (VS) within the reward network demonstrates links to depressive disorders and anhedonia from mid to late adolescence, which indicates the role played by this circuitry in depression changes with age, reveals a study.

Solithromycin safe, effective in paediatric community-acquired bacterial pneumonia
Treatment with intravenous or oral solithromycin is well-tolerated and leads to clinical improvement in most children and adolescents with community-acquired bacterial pneumonia (CABP), results of a recent study have shown.

Can very low-risk breast cancer patients be spared from postop radiotherapy?
Adjuvant radiotherapy (RT) may be omitted in women with very low-risk breast cancer who have had breast conserving surgery (BCS) and have been receiving endocrine therapy, according to findings from the LUMINA study.




