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Novel MET kinase inhibitor counteracts TKI resistance in NSCLC
Treatment with SCC244, a novel small molecule inhibitor of the enzyme MET kinase, appears to help overcome the resistance to tyrosine kinase inhibitors (TKI) mediated by MET amplification in nonsmall cell lung cancer (NSCLC), reports a new study presented at the recent 2022 European Society for Medical Oncology Asia Congress (ESMO Asia 2022).
Add-on radiation therapy poses higher cardiovascular risk in stage III NSCLC
The addition of radiation therapy to chemotherapy may be more detrimental than beneficial in patients with resectable stage III nonsmall‐cell lung cancer (NSCLC), being associated with a heightened risk of severe cardiac events, as shown in a study.
Diabetes and COVID-19: What have we learned so far?
Evidence for excess risk and increased burden of new-onset diabetes among COVID-19 survivors is robust, and most antihyperglycaemic drugs can be used safely during acute COVID-19, with some drugs potentially offering protection against serious complications, according to data presented at 5th EDM HK.
Bacteraemia, UTI not uncommon in paediatric renal transplant recipients
A few paediatric renal transplant recipients who presented with suspected infection within 2 years of transplant were diagnosed with bacteraemia or urinary tract infections (UTIs) or both, reports a study. Evaluations are highly variable, with a third of visits without urine cultures obtained.
Progestin shows therapeutic potential in PR-positive endometrial cancer
Progestin therapy appears to yield high response rates in advanced stage and recurrent endometrial cancer that is positive for progesterone receptor (PR) expression, while having low toxicity, according to a study.
