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BP awareness, drug adherence help prevent death, morbidity in stroke patients
Encouraging people to check their blood pressure (BP) regularly and boost adherence to antihypertensive medications can potentially reduce stroke mortality and morbidity, suggests a study. Improving the literacy level and reducing the smoking rate may help achieve these goals.

Metastatic castration-sensitive prostate cancer: When is it preferable to use triplet, doublet therapies?
In patients with metastatic castration-sensitive prostate cancer, triplet therapy may be ideal for fit patients with synchronous (de novo) high-volume disease while the androgen pathway inhibitor (API) doublet combinations may be preferred for those with metachronous (recurrent) low-volume disease, according to the results of a meta-analysis.

mHSPC: Adding darolutamide to ADT and docetaxel ups OS in most disease volume and risk subgroups
Triplet therapy with darolutamide, androgen-deprivation therapy (ADT) and docetaxel improves overall survival (OS) by approximately 30 percent vs ADT plus docetaxel in most disease volume and risk subgroups of patients with metastatic hormone-sensitive prostate cancer (mHSPC), a post hoc analysis of the phase III ARASENS trial has shown.

Novel intravaginal device for postpartum bleeding passes muster in phase II trial
A less invasive intravaginal device that facilitates bimanual uterine compression appears to work well in the treatment of postpartum haemorrhage, according to the results of a phase II trial.

Selgantolimod well tolerated, induces serologic changes in CHB
Treatment with the oral Toll-like receptor 8 (TLR8) agonist selgantolimod once weekly for 24 weeks is well tolerated and generally safe in patients with chronic hepatitis B (CHB) under viral suppression, according to a recent study.

Gene links breast cancer to stress, circadian disruption
Two researchers from the Philippines have discovered a gene the connects breast cancer development to stress and body clock disruption. In a recent study, they have shown the mechanism behind hormone and circadian regulation of the tumour-suppressor gene, Krüppel-like factor 9 (KLF9), and its effect on breast cancer progression.

Deep-brain stimulation affords greater seizure reduction than vagus nerve stimulation
Among the neurostimulation devices used in the treatment of generalized epilepsy, deep-brain stimulation performs better than vagus nerve stimulation at reducing seizure frequency, as reported in a study. On the other hand, while results for responsive neurostimulation are promising, further research is needed.

