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Systemic therapies effective in melanoma of unknown primary
Patients with melanoma of unknown primary (MUP) benefit from novel therapies similarly as those with stage-matched melanoma of known cutaneous primary (cMKP) despite having less favourable baseline prognostic factors, reveals a study.
SLN status optimizes adjuvant therapy decision-making in clinical stage IIB/C melanoma
The performance of a prognostic model with sentinel lymph node (SLN) biopsy status in assessing patient risk for 5-year melanoma-specific death is superior to that of a model with primary tumour staging factors alone for threshold mortality rates ≥30 percent, a study has shown.
Frailty may portend cognitive decline
Initial frailty status appears to be a potential predictor of the occurrence of the composite of probable dementia and mild cognitive impairment, and this association is strengthened by intensive blood pressure control, as reported in a study.
Adapted digital cognitive behavioural therapy helps the sleepless get better night's sleep
A smartphone-based Chinese culture-adapted digital cognitive behavioural therapy for insomnia (DCBT-I) appears beneficial, producing improvements in the severity of insomnia as compared with sleep education, according to a study.
