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New drug applications approved by US FDA as of 01-15 November  2023 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Among patients with recurrent gastrointestinal (GI) bleeding due to small-intestinal angiodysplasia (SIA), treatment with thalidomide resulted in fewer bleeding episodes compared with placebo, according to a recent study.

Use of apixaban appears to reduce the risk of gastrointestinal haemorrhage (GIH) compared with dabigatran, rivaroxaban, and vitamin K antagonist (VKA) in patients with nonvalvular atrial fibrillation, a recent study has shown. On the other hand, rivaroxaban use tends to increase GIH risk relative to dabigatran and VKA.

Insertion of self-expandable metal stents (SEMS) for acute malignant large bowel obstruction (MBO) results in high technical and clinical success with a favourable safety profile, as shown in a recent Singapore study.

Use of endoscopic vacuum therapy (EVT), a new technique for closing upper gastrointestinal (UGI) defects, results in the closure of defects, such as anastomotic leak and perforations of the upper digestive tract, with only a few serious adverse events (AEs), a study has shown.