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Sacituzumab govitecan proven safe, effective in metastatic breast cancer
Treatment with sacituzumab govitecan (SG) demonstrates clinically meaningful overall survival (OS) over single-agent chemotherapy in patients with pretreated, endocrine-resistant, hormone receptor–positive/HER2-negative (HR+/HER2–) metastatic breast cancer (mBC), as confirmed by the final OS analysis from the TROPiCS-02 study, presented at ASCO 2023.
Debunking the myth: There is no ‘obesity paradox’, new data suggest
Using alternative anthropometric measurements, a post hoc analysis that used data from the PARADIGM-HF* trial debunked the BMI-related ‘obesity paradox’ in a large cohort of patients with chronic heart failure with reduced ejection fraction (HFrEF).
Neutrophilia, leukocytosis tied to poor outcomes in paediatric liver abscess
In children with liver abscess, factors such as age-related leukocytosis, neutrophilia, elevated aspartate transaminase or alanine transaminase, and hypoalbuminaemia at presentation are significantly associated with poor outcomes, suggests a study.
Mediterranean diet counselling may help counter overweight/obesity in the offspring
A personalized nutritional counselling targeting adherence to the Mediterranean diet (MD) during pregnancy may be an effective strategy against childhood overweight/obesity, findings from the PREMEDI study have shown.