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A novel risk score, PAGED-B, may be used to predict hepatocellular carcinoma (HCC) development at the time of transition into hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB), suggests a study.

20 Jan 2024

Shortened terlipressin therapy after endoscopic haemostasis as effective as 3-day course

In cirrhosis patients with acute variceal bleeding (AVB), treatment with terlipressin for a single day yields similar rebleeding and mortality rates as 3-day treatment following endoscopic haemostasis, while having an overall superior safety profile, according to a study.

Linaclotide improves bowel movement frequency in children with functional constipation

20 Jan 2024 bởi

Once-daily treatment with linaclotide, a guanylate cyclase C agonist, significantly improved the frequency of spontaneous bowel movements (SBMs) in paediatric patients with functional constipation, according to a recent study.

Probiotic Bif195 helps protect against aspirin-induced stomach damage

The probiotic strain Bifidobacterium breve (Bif195), when co-administered with aspirin, appears to mitigate stomach injury caused by aspirin, according to the results of a randomized crossover trial.

HCC incidence rare in autoimmune hepatitis, tied to obesity, cirrhosis

The incidence of hepatocellular carcinoma (HCC) remains low in patients with autoimmune hepatitis (AIH) even after developing cirrhosis, according to a study. Factors such as obesity, cirrhosis, and AIH/primary sclerosing cholangitis (PSC) variant syndrome can increase the risk of HCC incidence.

19 Jan 2024

Parental smoking, asthma, respiratory tract infections in childhood linked to adult OSA

Parental smoking, maternal asthma, and frequent lower respiratory tract infections before the age of 7 years are predictive of obstructive sleep apnoea (OSA) development during adulthood, suggests a study.

19 Jan 2024

Tacrolimus outclasses cyclosporine after liver transplantation for PSC

Tacrolimus appears to be more effective than cyclosporine in improving patient and graft survival after liver transplantation (LT) for primary sclerosing cholangitis (PSC), results of a study have shown.

TaTME-DCAA feasible for low rectal cancer

A retrospective, propensity score-matched analysis from Singapore demonstrates the feasibility of transanal total mesorectal excision with delayed coloanal anastomosis (TaTME-DCAA) as a surgical alternative for non-metastatic low rectal cancer.

Linaclotide works well for functional constipation in children

The guanylate cyclase C agonist linaclotide helps increase the frequency of bowel movements in children with functional constipation, according to data from a phase III trial.