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Bevacizumab + EGFR-TKI improves OS in EGFR-mutated NSCLC with leptomeningeal metastases
Adding bevacizumab to an EGFR tyrosine kinase inhibitor (TKI) improves overall survival (OS) in adult patients with EGFR-mutated non-small-cell lung cancer (NSCLC) and leptomeningeal metastases (LMs), according to a single-centre, retrospective, real-world study in China. OS was, however, similar between patients on chemotherapy plus EGFR-TKI and those on EGFR-TKI monotherapy.
Rectal spacers in MR-guided SBRT for localized prostate cancer very well tolerated, improve rectal sparing and target coverage
Clinical outcomes within 1 year of MR-guided stereotactic body radiation therapy (MRgSBRT) with rectal spacer for patients with localized prostate cancer (PC) show excellent tolerability, minimal gastrointestinal (GI) toxicity as well as improved rectal sparing and target coverage vs a non-spacer comparison cohort.
Dupilumab mends skin barrier in children with AD, but with caveat
Use of dupilumab results in normalization of stratum corneum (SC) lipids, which is responsible for skin barrier function, in children with atopic dermatitis (AD) within 1 to 2 months of treatment, according to a study presented at AAAAI 2024.
