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Palliative care for interstitial lung disease more difficult than for lung cancer

Providing palliative care (PC) for patients with interstitial lung disease (ILD) appears more challenging than for those with lung cancer (LC), according to a study. Pulmonary specialists have also cited some ILD-specific barriers in PC.

Palliative care for interstitial lung disease more difficult than for lung cancer

11 Jul 2023

Differential response to donepezil across MCI subtypes

11 Jul 2023 bởi

A double-blind randomized controlled trial (RCT) finds that donepezil offers greater benefit in mild cognitive impairment (MCI) among individuals with hippocampal-sparing or minimal atrophy subtype vs individuals with typical or limbic-predominant patterns of atrophy.

Differential response to donepezil across MCI subtypes

KEYNOTE-826: Sustained survival benefit with pembro + chemo in advanced cervical cancer

11 Jul 2023 bởi

The addition of pembrolizumab immunotherapy to chemotherapy, either with or without bevacizumab, continues to confer survival benefit in patients with persistent, recurrent, or metastatic cervical cancer, regardless of their programmed death-ligand 1 (PD-L1) combined positive score (CPS), according to the updated results of the KEYNOTE-826 trial presented at ASCO 2023.

KEYNOTE-826: Sustained survival benefit with pembro + chemo in advanced cervical cancer

Spesolimab curbs flares in generalized pustular psoriasis

The anti-interleukin (IL)-36 receptor monoclonal antibody spesolimab not only helps treat generalized pustular psoriasis (GPP) flares but also prevent them, according to the results of the Effisayil 2 study presented at WCD 2023.

Spesolimab curbs flares in generalized pustular psoriasis

$Tocilizumab an effective substitute to anti-TNF agents in refractory Behçet disease$

Tocilizumab an effective substitute to anti-TNF agents in refractory Behçet disease

Tocilizumab (TCZ) may be used as an alternative treatment to antitumour necrosis factor (anti-TNF) agents for patients with Behçet disease (BD)-related uveitis and neurological manifestations, a recent study has shown.

Tocilizumab an effective substitute to anti-TNF agents in refractory Behçet disease

Does polypharmacy affect survival in older patients with haematological malignancy?

Polypharmacy does not appear to result in poorer treatment response and survival in older patients with different haematological malignancies, as shown in a study presented at the recent EHA 2023.

Does polypharmacy affect survival in older patients with haematological malignancy?

Certain drugs, antinuclear antibodies linked to GI dysfunction in SSc

A phenome-wide association study (pheWAS) has found known and potentially new risk factors for gastrointestinal (GI) dysfunction in systemic sclerosis (SSc), which include drug classes such as opioid, antimuscarinic, and endothelin receptor antagonist, and antinuclear antibodies (ANAs) subgroup.

Certain drugs, antinuclear antibodies linked to GI dysfunction in SSc

Novel hepcidin mimetic shows remarkable potential for polycythemia vera

In the three-part, phase II REVIVE study, the investigational, first-in-class hepcidin mimetic rusfertide was highly effective in regulating haematocrit levels in individuals with polycythemia vera (PV) who had a high phlebotomy burden.

Novel hepcidin mimetic shows remarkable potential for polycythemia vera

Vorasidenib may be chemo–RT-sparing in certain low-grade gliomas

The oral drug vorasidenib delays disease progression compared with placebo in patients with residual or recurrent grade 2 gliomas harbouring an isocitrate dehydrogenase 1 or 2 (IDH1 or IDH2) mutation in the phase III INDIGO trial.

Vorasidenib may be chemo–RT-sparing in certain low-grade gliomas