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In patients with atrial fibrillation (AF), off-label underdosed apixaban leads to lower plasma apixaban concentrations than on-label standard and reduced-dose regimens, according to a study.

Monitor apixaban concentrations in AF patients, says study

TOPSPIN highlights three dual combo pills for BP control

10 Dec 2024 bởi

Three dual combinations of commonly prescribed antihypertensives – amlodipine and perindopril, perindopril and indapamide, or amlodipine and indapamide – demonstrated equal blood pressure (BP)-lowering efficacy among Indian adults, according to the results of the TOPSPIN trial presented at AHA 2024.

TOPSPIN highlights three dual combo pills for BP control

10 Dec 2024

Nirmatrelvir-ritonavir efficacy and risk factors for COVID-19 hospitalization

The post-pandemic burden of COVID-19 remains significant in adults. Four studies from IDWeek 2024 highlight the benefits of nirmatrelvir-ritonavir (NMV/r) for high-risk adults with SARS-CoV-2 immunity and link chronic conditions to COVID-19 hospitalization. Identifying high-risk patients and using NMV/r in outpatient settings can reduce severe outcomes.

Nirmatrelvir-ritonavir efficacy and risk factors for COVID-19 hospitalization

CV risk and obesity associated with reduced brain volume earlier in males than females

10 Dec 2024 bởi

The detrimental influence of cardiovascular (CV) risk and obesity on grey matter volume impacts males a decade earlier than females, a recent UK study has found.

CV risk and obesity associated with reduced brain volume earlier in males than females

Cardiometabolic risk factors mediate link between body composition, bone mineral content

08 Dec 2024

The number of cardiometabolic risk (CMR) factors plays an important role in mediating the association between fat percentage and bone mineral content (BMC) percentage in children, suggests a study.

Cardiometabolic risk factors mediate link between body composition, bone mineral content

08 Dec 2024

Smoking ups risk of both heart failure subtypes

Cigarette smoking appears to be a significant risk factor for the incidence of both subtypes of heart failure (HF), regardless of baseline lung function, according to a study.

Smoking ups risk of both heart failure subtypes

Clinical considerations for patients at high risk for progression to severe COVID-19

COVID-19 has not gone away. New contagious variants continue to be a leading cause of death, with underlying conditions still influencing the risk of COVID-19 hospitalizations, said Dr Ali Hassoun, Clinical Professor of Medicine and infectious disease specialist at Crestwood Medical Center, Huntsville, Alabama, US, who spoke at a Pfizer-sponsored session during IDWeek 2024.

Clinical considerations for patients at high risk for progression to severe COVID-19

Myocarditis does not worsen cardiac arrest outcomes

Prior myocarditis or perimyocarditis does not factor in out-of-hospital cardiac arrest (OHCA) outcomes, but the presence of concomitant heart failure (HF) may contribute to unfavourable outcomes in the short and long term, as suggested in a study.

Myocarditis does not worsen cardiac arrest outcomes

Original New Drug Application Approvals by US FDA (16-30 November 2024)

New drug applications approved by US FDA as of 16-30 November 2024 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16-30 November 2024)