Tin tức & Cập nhật

Switching to a fulvestrant-palbociclib regimen prior to disease progression after detection of elevated ESR1 mutations in the blood of patients with hormone receptor-positive (HR+), HER2-negative (HER2-) metastatic breast cancer (mBC) who were receiving aromatase inhibitors (AIs) plus palbociclib extended their progression-free survival (PFS), results of the phase III PADA-1 trial showed.

A recent study has shown that more than a quarter of young adults are seropositive for SARS-CoV-2, many of whom show single positivity with IgM. Such seropositivity was higher among those who had cases of the coronavirus disease 2019 (COVID-19) in the household and those who used public transport.

Autoimmune hepatitis (AIH), a chronic inflammatory liver disease, appears to increase the 10-year risk of cancer by 1.5-fold relative to age- and sex-matched controls, a study has shown.

Antihypertensive therapy (AHT) may be used safely during the COVID-19 pandemic, as no evidence suggest that it can increase the risk of SARS-CoV-2 infection or death, according to a UK study. In addition, most classes of antihypertensives are negatively associated with COVID-19 diagnosis.

The 3-dimensional (3D) deep learning-based automated digital gonioscopy system (DGS) effectively identifies eyes with suspected primary angle-closure glaucoma (PACG), demonstrating its potential for wide use in the primary eye care community for screening of patients at high risk of developing PACG, suggests a study.

The benefits of the 5:2 diet – which involves limited caloric intake (500–600 kcal) for 2 nonconsecutive days per week only – mirrored those achieved with a multicomponent weight management advice, according to a UK study on adults with obesity. However, the benefits eventually waned, even when intensified with group support.

In patients with neovascular age-related macular degeneration (nAMD), the presence of intraretinal fluid (IRF) and subretinal hyper-reflective material (SHRM) seem to increase the likelihood of subretinal fibrosis (SF), a recent study has found.

Adding duloxetine to usual care does not appear to produce significant relief from chronic osteoarthritis pain as compared with usual care alone, a study has found.