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In Crohn’s disease patients with inadequate response or intolerance to conventional or biologic therapy, guselkumab, a selective p19 interleukin (IL)-23 antagonist, appears effective by yielding better clinical and endoscopic improvements than placebo, a recent study has found.

Lupus nephritis carries higher adverse outcomes in kids on dialysis

Among children and adolescents undergoing maintenance dialysis, those with lupus nephritis are at higher risk of adverse outcomes, including hospitalization, and are less likely to receive kidney transplantation compared with those who have non-lupus glomerular disease, a study has found.

Adjunctive mavacamten averts need for invasive therapy in OHCM

28 Apr 2022 bởi

Adding mavacamten – an allosteric modulator of cardiac myosin – to maximal medical therapy slashes the need for septal reduction therapy (SRT) in patients with obstructive hypertrophic cardiomyopathy (OHCM) who are candidates for such intervention, the VALOR-HCM trial has shown.

Annual flu jab in HF patients may lower hospitalization, pneumonia risk

An annual influenza vaccination does not lower the risk of cardiovascular (CV) outcomes in patients with heart failure (HF), though it may reduce the risk of pneumonia and hospitalization, according to results of the IVVE study presented at ACC.22.

27 Apr 2022

Hypertriglyceridemia tied with severe acute pancreatitis

The risk of severe acute pancreatitis appears to be significantly and independently associated with hypertriglyceridemia, reports a recent study.

27 Apr 2022

Stem cells may hold the answer to our problems associated with ageing and frailty.

Frailty is an age-related disability characterized by generalized weakness, impaired mobility and balance, poor endurance, and decline in organ physiologic reserve and loss of homeostasis. It is a syndrome of multisystem reduction in physical capacity (caused by muscle loss) that leads to loss of independence.

Rhythm control should be started earlier in women vs men

Early initiation of rhythm control for atrial fibrillation (AF) appears to be favourable, but women should start rhythm control treatment earlier than men to get the best possible outcomes, according to a study presented at the annual meeting of the European Heart Rhythm Association (EHRA).

Urinary angiotensinogen linked to renal arteriolar remodeling in CKD

Renal renin‒angiotensin system (RAS) appears to contribute to renal arteriolar remodeling and future decline in estimated glomerular filtration rate (eGFR), irrespective of potential risk factors, in patients with chronic kidney disease (CKD), a study has found.

Cochlear implant corrects hearing but does not translate to actual perceived benefits

Cochlear implantation (CI) improves both audiologic and tinnitus outcome measures in patients with single-sided deafness (SSD), but the speech discrimination score (SDS) remains in nonserviceable range, while only a modest improvement is seen in quality-of-life (QoL) measures, reports a Singapore study.

Long-term antihypertensive therapy beneficial for myocardial strain

Antihypertensive treatment provides benefits on left ventricular (LV) mechanisms, suggest the results of a meta-analysis, noting that improvement in global longitudinal strain (GLS) is associated with the reduction in LV mass index (LVMI) instead of systolic blood pressure (SBP).