|
Chỉ định và Liều dùng
Intravenous
Paget's disease of bone Adult: As 2nd or 3rd line of treatment: 25 mcg/kg/day by slow infusion for 15 doses followed by 1500 mcg wkly for 2 mth, then every 2 wk for 6 wk. Intravenous Hypercalcaemia and hypercalciuria associated with malignancy Adult: 25 mcg/kg by slow infusion over 4-6 hr. May be repeated several times at intervals of 24-72 hr.
|
|
Chống chỉ định
Pregnancy and lactation. Hypersensitivity.
|
|
Thận trọng
Impaired hepatic or renal function. Extravasation. Monitor CBC and electrolytes before each treatment; blood cell counts, coagulation time, hepatic and renal function frequently during treatment and several days after. Patients with coagulopathy.
|
|
Tác dụng không mong muốn
Dose-related bleeding syndrome, manifested initially as epistaxis. GI effects, metallic taste, mild stomatitis; fever, malaise, drowsiness, lethargy, weakness, headache, depression; skin rashes, facial flushing; reduced serum concentrations of calcium, phosphorus and potassium; reversible renal or hepatic impariment; transient elevated hepatic enzymes; extravasation may cause local irritation, cellulitis and phloebitis.
Potentially Fatal: Epitaxis progressing to haematemesis and fatal haemorrhage. Severe thrombocytopaenia due to bone marrow depression. |
|
Tương tác
Admixture with trace element solutions. Chelates divalent cations eg iron.
|
|
Tác dụng
Description:
Mechanism of Action: Plicamycin, a highly toxic antibiotic with antineoplastic and hypocalcaemic properties, is cell-cycle phase-nonspecific that binds to DNA in the presence of divalent cations and inhibits synthesis of RNA. Its hypocalcaemic activity is due to blocking PTH action on osteoclasts. |
|
Bảo quản
Store at 2-8°C.
|
|
Phân loại MIMS
|
Đăng ký miễn phí để được tiếp tục đọc
Tiếp tục với Google
Đăng ký với email
Đã là thành viên?
Đăng nhập
Đăng xuất
