Piperazine

Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Enterobiasis
Adult: As piperazine hydrate: 2,000-2,250 mg daily given as a single or in divided doses for 7 days. May repeat course after 1-week interval in severe infections.
Child: As piperazine hydrate: 1-2 years 375 mg; 2-4 years 750 mg; 5-12 years 1,500 mg; >12 years Same as adult dose. All doses are given daily as a single or in divided doses for 7 days. May repeat course after 1-week interval in severe infection.

Oral
Ascariasis
Adult: As piperazine hydrate: 4,000-4,500 mg as a single dose with the evening meal. If patient is constipated, administer laxative in the morning after treatment to facilitate expulsion of worms. Dosing recommendations may vary among individual products. Refer to specific product guidelines.
Child: As piperazine hydrate: 1-2 years 1,125-1,333 mg; 3-8 years 2,250-2,666 mg; 9-12 years: 3,000 mg; >12 years Same as adult dose. All doses to be taken as a single dose with the evening meal. If patient is constipated, administer laxative in the morning after treatment to facilitate expulsion of worms. Dosing recommendations may vary among individual products. Refer to specific product guidelines.
Suy thận
Severe: Contraindicated.
Suy gan
Contraindicated.
Cách dùng
May be taken with or without food.
Chống chỉ định
History of epilepsy. Severe renal impairment. Hepatic impairment. Pregnancy.
Thận trọng
Patient with anaemia, severe malnutrition, neurological disturbances. Mild to moderate renal impairment. Children. Lactation.
Tác dụng không mong muốn
Eye disorders: Blurred vision, nystagmus, cataracts (rare).
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain.
Immune system disorders: Hypersensitivity reactions (e.g. bronchospasm, angioedema, urticaria, Stevens-Johnson syndrome).
Musculoskeletal and connective tissue disorders: Muscular incoordination and weakness.
Nervous system disorders: Ataxia, headache, dizziness, drowsiness, paraesthesia, myoclonic contractions (if renal or neurological disease exist), choreiform movements, tremor, seizure, hyporeflexia.
Psychiatric disorders: Confusion.
Chỉ số theo dõi
Examine stool for worms and ova.
Tương tác
May potentiate the adverse effects of phenothiazines (e.g. chlorpromazine). Antagonised anthelmintic effect with pyrantel pamoate.
Tác dụng
Description:
Mechanism of Action: Piperazine is an anthelmintic effective against Ascaris lumbricoides (roundworm) and Enterobius vermicularis (threadworm/pinworm). It blocks the effect of acetylcholine at the neuromuscular junction which causes flaccid paralysis to roundworms, which are then dislodged by the movement of the gut and expelled in the faeces. Its mode of action against threadworm is not fully elucidated.
Pharmacokinetics:
Absorption: Readily absorbed from the gastrointestinal tract.
Distribution: Enters breast milk.
Excretion: Via urine (partly as metabolites).
Đặc tính

Chemical Structure Image
Piperazine

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 4837, Piperazine. https://pubchem.ncbi.nlm.nih.gov/compound/Piperazine. Accessed July 26, 2021.

Bảo quản
Storage recommendations may vary among individual products. Refer to specific product guidelines.
Phân loại MIMS
Thuốc trừ giun sán
Phân loại ATC
P02CB01 - piperazine ; Belongs to the class of piperazine and derivatives agents. Used as antinematodal.
Tài liệu tham khảo
Anon. Piperazine (Briggs Drugs in Pregnancy and Lactation). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/07/2021.

Anon. Piperazine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/07/2021.

Ascalix Syrup 4 g/30 mL (Wallace Manufacturing Chemists Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 12/07/2021.

Ascalix Syrup 750 mg/5 mL (Wallace Manufacturing Chemists Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 12/07/2021.

Buckingham R (ed). Piperazine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/07/2021.

Preston CL (ed). Piperazine + Chlorpromazine. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/07/2021.

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