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Chỉ định và Liều dùng
Oral
Type 2 diabetes mellitus Adult: 200-400 mg bid.
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Chống chỉ định
Insulin-dependent diabetes, diabetic coma, ketoacidosis, trauma, severe infection, heart failure, recent MI; dehydration. Renal or hepatic impairment.
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Thận trọng
Monitor vitamin B12 concentrations annually during long-term treatment. Pregnancy.
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Tác dụng không mong muốn
Anorexia, nausea, vomiting, diarrhoea, metallic taste, wt loss, skin reactions, acute pancreatitis.
Potentially Fatal: Lactic acidosis, CV adverse effects. |
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Quá liều
Symptoms: Lactic acidosis. Treatment: Intensive supportive therapy. Glucose or glucagon may be given if hypoglycaemia is present.
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Tương tác
May impair vitamin B12 absorption.
Potentially Fatal: Cimetidine may reduce renal clearance of phenformin. Increased risk of lactic acidosis with alcohol, nephrotoxic drugs. |
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Tác dụng
Description:
Mechanism of Action: Phenformin is a biguanide antidiabetic. It does not stimulate insulin release but requires the presence of insulin to exhibit its hypoglycaemic effect. It delays glucose absorption from the GI tract, increases insulin sensitivity and glucose uptake, and inhibits gluconeogenesis in the liver. Pharmacokinetics: Metabolism: Hepatic. |
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Phân loại MIMS
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