Peptic ulcer
Adult: 5-10 mg bid or tid
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Chỉ định và Liều dùng
Oral
Peptic ulcer Adult: 5-10 mg bid or tid
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Chống chỉ định
Closed-angle glaucoma; obstructive uropathy; GI obstruction, paralytic ileus, intestinal atony, ulcerative colitis; toxic megacolon; myasthenia gravis.
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Thận trọng
Elderly; autonomic neuropathy; hepatic or renal disease; hyperthyroidism, CHF, thyrotoxicosis, MI, tachyarrhythmias, hypertension, prostatic hypertrophy; hiatal hernia. May impair ability to drive or operate machinery. Pregnancy and lactation. Down's syndrome.
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Tác dụng không mong muốn
Xerostomia, decreased sweating, urinary hesitancy and retention, blurred vision, cycloplegia, increased ocular tension, loss of taste, headache, nervousness, mental confusion, impotence, suppression of lactation, urticaria, constipation.
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Quá liều
Symptoms range from increased side effects to CNS disturbances, circulatory changes, respiratory failure, paralysis and coma. treat with immediate gastric lavage and injection of physostimine 0.5-2 mg up to a total of 5 mg. Treat symptomatically and supportively.
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Tương tác
Enhanced effect with concurrent admin of other drugs with antimuscarinic properties and MAOIs. May affect absorption of other drugs. Antagonistic effect with parasympathomimetics.
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Tác dụng
Description:
Mechanism of Action: Oxyphencyclimine is a tertiary amine antimuscarinic. It blocks all three types of muscarinic receptors and inhibits vagally mediated reflexes by antagonising the action of acetylcholine. |
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Phân loại MIMS
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