Oxolinic acid

Hypersensitivity. Severe renal impairment. Pregnancy and lactation. G6PD deficiency. Children. Convulsive conditions.

Impaired renal or hepatic function; exposure to strong sunlight. Elderly.

Urinary stones, muscle pain, hypersensivity reactions (e.g. rash, urticaria, pruritus, photosensitivity, leukopenia, eosinophilia), nausea, vomiting, anorexia, epigastric pain, abdominal pain, diarrhoea, metallic taste, increased LFTs, insomnia, anxiety, nervousness, confusion, vertigo, somnolence, headache, peripheral neuropathy, paraesthesia, photophobia, blurred vision, disturbances in accommodation, diplopia, convulsions, hallucination.

Description:
Mechanism of Action: Oxolinic acid is a quinolone antibacterial agent with properties similar to nalidixic acid. It interferes with bacterial DNA replication probably by inactivating bacterial DNA gyrase (type II topoisomerase).
Pharmacokinetics:
Absorption: Absorbed in the GI tract. Peak plasma concentration in 30-60 min.
Distribution: Protein-binding: 80%.
Metabolism: Hepatic.
Excretion: Via urine. Half-life: 4-6 hr.

Quinolon