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Chỉ định và Liều dùng
Oral
Contraception Adult: Take 1 tablet (30 mg) twice a wk for the 1st 12 wk then 1 tablet (30 mg) once a wk from 13th wk onwards. Take 1st tablet on the 1st day of menstrual cycle. Follow dose irrespective of menstrual periods. Oral Dysfunctional uterine bleeding Adult: 60 mg twice a wk for the 1st 12 wk and then 60 mg once a wk for up to next 12 wk.
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Chống chỉ định
Polycystic ovarian disease, cervical hyperplasia, recent history of jaundice or hepatic impairment, severe allergic states, TB, renal impairment. Pregnancy and lactation.
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Thận trọng
Women who desire to be pregnant should discontinue taking the drug.
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Tác dụng không mong muốn
Delayed menses.
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Tác dụng
Description:
Mechanism of Action: Ormeloxifene acts on oestrogen receptors. It has a weak estrogenic and potent antiestrogenic actions. It is expected to exert a contraceptive effect and normalise the bleeding from uterine cavity by regularising the expression of oestrogen receptors on the endometrium. As a contraceptive, it prevents proliferation and decidualisation of the endometrium, enhances blastocyst formation and slightly increases embryo transport through the oviducts. Pharmacokinetics: Absorption: Well absorbed from the GI tract. Peak serum levels achieved in 4 hr. Distribution: Widely distributed in tissues. Little affinity to plasma proteins. Excretion: Terminal half-life: Approx 170 hr. |
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Phân loại MIMS
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