Mesterolone

May be taken with or without food.

Prostatic carcinoma, current or history of liver tumours.

Patient with a history of MI or CAD; conditions influenced by oedema (e.g. CV disease, seizure, migraine), polycythaemia. Not indicated for use in women. Not indicated for enhancing muscular development or physical ability in healthy individuals. Renal and hepatic impairment.

Significant: Frequent or persistent erections, excessive sexual stimulation; increased risk of prostate cancer; VTE.
Potentially Fatal: Rarely, benign or malignant liver tumours, intra-abdominal haemorrhage.

Monitor lipid profile. Perform prostate examination prior to starting therapy and routinely during therapy.

May interfere with thyroid function test and glucose tolerance test.

Description:
Mechanism of Action: Mesterolone is an orally active androgen with less inhibitory effect on intrinsic testicular function than testosterone. It stimulates receptors in tissues and organs to promote the growth and development of male sex organs and to maintain secondary sex characteristics in androgen-deficient males.
Pharmacokinetics:
Absorption: Rapidly and almost completely absorbed. Bioavailability: 3%. Time to peak plasma concentration: 1.6 ± 0.6 hours.
Distribution: Plasma protein binding: 98% (40% to albumin and 58% to sex hormone binding globulin).
Metabolism: Rapidly metabolised in the liver into metabolites including 1α-methylandrosterone and 1α-methyl-5α-androstane-3α, 17β-diol.
Excretion: Via urine (80% as metabolites); faeces (13% as metabolites). Elimination half-life: 12-13 hours.

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 15020, Mesterolone. https://pubchem.ncbi.nlm.nih.gov/compound/Mesterolone. Accessed Feb. 23, 2023.

Store below 30°C.

Androgen & các thuốc tổng hợp có liên quan

G03BB01 - mesterolone ; Belongs to the class of 5-androstanon (3) derivative androgens used in androgenic hormone preparations.

Anon. Mesterolone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/11/2022.

Buckingham R (ed). Mesterolone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/11/2022.

Pro-viron (Bayer PLC). MHRA. https://products.mhra.gov.uk. Accessed 16/11/2022.