Mazindol

Should be taken with food.

Narrow-angle glaucoma; severe renal or hepatic impairment; cerebrovascular or CV disease, pulmonary artery hypertension, severe arterial hypertension, anorexia nervosa, depression, hyperexcitability and agitation, history of or predisposition to drug abuse, known alcoholism. Lactation. Children <12 yr.

DM, psychosis, epilepsy, prolonged treatment. Ensure gradual and controlled wt loss in obese patients. Cardiac murmur or cardiac valve abnormalities. May impair ability to drive or operate machinery. Elderly. Pregnancy.

Nervousness, agitation, dizziness, drowsiness, depression, psychosis, vertigo, insomnia, dryness of mouth, headache, tremor, hallucination, paraesthesia, anxiety, convulsion, tachycardia, palpitation, precordial pain, hypertension, pulmonary artery hypertension, diarrhoea, taste disturbance, asthenia, skin reaction, sexual dysfunction, menstrual disorder, sweating, flushing, dysuria.

Additive effects with other centrally acting anorectics. Significant hypertension with MAOIs. Increased risk of lithium toxicity.

Description:
Mechanism of Action: Mazindol is a central stimulant which acts by inhibiting the reuptake of dopamine and noradrenaline. It has been used as an anorectic in the treatment of obesity but stimulants are no longer recommended for this indication.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract.
Excretion: Via urine (as metabolite and unchanged drug).

Store at room temperature.

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