Loracarbef

Patients with CrCl of 10-49 mL/min: Half the usual dose at the usual dosage interval or full dose at twice the usual interval; <10 mL/min: Usual dose every 3-5 days. Patients on haemodialysis should receive another dose following dialysis.

Should be taken on an empty stomach.

Hypersensitivity to β-lactams.

Impaired renal function, history of colitis.

Diarrhoea, nausea, vomiting, abdominal pain; headache; skin rashes; abnormalities in haematological parameters; elevations in hepatic enzymes, hepatic dysfunction.

PO: B

Plasma concentration is increased by probenecid.

Description:
Mechanism of Action: Loracarbef is a carbacephem antibiotic. It is bactericidal through binding to essential target proteins of the bacterial cell wall, leading to inhibition of cell-wall synthesis, thus preventing cell division.
Pharmacokinetics:
Absorption: Well absorbed from GI tract. Peak plasma levels after 1.2 hr (capsule) or 40-60 min (liquid). Absorption delayed significantly by food.
Distribution: 25% bound to plasma proteins.
Excretion: Excreted in the urine as unchanged drug.

Các beta-lactam khác